Journal article
Crosslinked Polypeptide Films via RAFT-Mediated Continuous Assembly of Polymers
NJ Chan, S Lentz, PA Gurr, S Tan, T Scheibel, GG Qiao
Angewandte Chemie International Edition | WILEY-V C H VERLAG GMBH | Published : 2022
Abstract
Polypeptide coatings are a cornerstone in the field of surface modification due to their widespread biological potential. As their properties are dictated by their structural features, subsequent control thereof using unique fabrication strategies is important. Herein, we report a facile method of precisely creating densely crosslinked polypeptide films with unusually high random coil content through continuous assembly polymerization via reversible addition–fragmentation chain transfer (CAP-RAFT). CAP-RAFT was fundamentally investigated using methacrylated poly-l-lysine (PLLMA) and methacrylated poly-l-glutamic acid (PLGMA). Careful technique refinement resulted in films up to 36.1±1.1 nm t..
View full abstractGrants
Awarded by Deutscher Akademischer Austauschdienst
Funding Acknowledgements
This work was performed in part at the Materials Characterization and Fabrication Platform (MCFP) at the University of Melbourne. We further thank Prof. Laforsch for access to the Harrick VariGATR. S.L thanks Markus Hund for technical assistance with AFM measurements. N.J.C thanks The University of Melbourne for providing Australian Government Research Training Program Scholarship (AGRTP) for providing funds for travel. This work is supported by grants DFG SCHE603/23-1. N.J.C., S.L., G.G.Q. and T.S. acknowledge funding from the German Academic Exchange Service (DAAD) through its thematic network Bayreuth-Melbourne Colloid/Polymer Network sponsored from funds of the Federal Ministry of Education and Research (BMBF). Open Access funding enabled and organized by Projekt DEAL.